翼状胬肉发病机制的研究进展

doi:10.3760/ cma.j.issn.1673-5803.2021.06.015

国际眼科纵览 ›› 2021, Vol. 45 ›› Issue (6): 546-550.doi: 10.3760/ cma.j.issn.1673-5803.2021.06.015

翼状胬肉发病机制的研究进展

张鑫姜亚萍陈轶卉

同济大学附属杨浦医院眼科，上海 200090

收稿日期:2021-04-13 出版日期:2021-12-22 发布日期:2021-12-22
通讯作者: 陈轶卉，Email：cyh80h@163.com
基金资助:
上海市杨浦区医学重点学科（YP19ZA01）

Research progress on the pathogenesis of pterygium

Zhang Xin, Jiang Yaping, Chen Yihui

Department of Ophthalmology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, China

Received:2021-04-13 Online:2021-12-22 Published:2021-12-22
Contact: Chen Yihui, Email: cyh80h@163.com
Supported by:
Project of Key Discipline of Yangpu District of Shanghai (YP19ZA01)

摘要/Abstract

摘要： 翼状胬肉是一种常见的眼表疾病，长期慢性紫外线辐射是其发生的最主要因素，紫外线引起的氧化应激、慢性炎症、增生与凋亡、细胞外基质重塑以及遗传是翼状胬肉发病的重要机制。除P53基因突变外，表观遗传学包括m6A甲基化、DNA甲基化以及各种非编码RNA调控也在翼状胬肉发病机制中起重要作用。（国际眼科纵览，2021, 45：546-550）

关键词: 翼状胬肉, 非编码RNA

Abstract: Pterygium is a common ocular surface disease. Long-term chronic ultraviolet radiation is the most important factor in the development of pterygium. The oxidative stress, chronic inflammation, hyperplasia and apoptosis, extracellular matrix remodeling and heredity caused by ultraviolet rays are important mechanisms of the pathogenesis of pterygium. In addition to the P53 gene mutations, epigenetics including m6A methylation, DNA methylation, and various non-coding RNA regulation are also found to play an important role in the pathogenesis of pterygium. (Int Rev Ophthalmol, 2021, 45: 546-550)

Key words: pterygium, non-coding RNA

张鑫姜亚萍陈轶卉. 翼状胬肉发病机制的研究进展[J]. 国际眼科纵览, 2021, 45(6): 546-550.

Zhang Xin, Jiang Yaping, Chen Yihui. Research progress on the pathogenesis of pterygium[J]. International Review of Ophthalmology, 2021, 45(6): 546-550.

翼状胬肉发病机制的研究进展

Research progress on the pathogenesis of pterygium

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